Current Result Document :
| 한글제목(Korean Title) |
과민성 방광 치료를 위한 이식형 후경골신경 자극기 개발 및 유효성 검증 |
| 영문제목(English Title) |
Development and Effectiveness Evaluation of implantable posterior tibial nerve stimulator for treatment of overactive bladder |
| 저자(Author) |
최은미
주재선
임봉희
이규성
박은경
Eunmi Choi
Jaesoon Joo
Bonghee Lim
Kyusung Lee
Eunkyoung Park
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| 원문수록처(Citation) |
VOL 45 NO. 01 PP. 2460 ~ 2463 (2022. 06) |
한글내용
(Korean Abstract) |
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영문내용
(English Abstract) |
Tibial nerve stimulation (TNS) is one of the neuromodulation methods used to treat an overactive bladder (OAB). However, the treatment mechanism is not accurately understood owing to significant differences in the results obtained from animal and clinical studies. This, this study was aimed to confirm the response of bladder activity to the different stimulation frequencies and to observe the duration of prolonged post-stimulation inhibitory effects following TNS. This study usedunanesthetized rats to provide a closer approximation of the clinical setting and evaluated the changed in bladder activity in response to 30 min of TNS at different frequencies. Moreover, we observed the long-term changes of poststimulation inhibitory effects. Our results showed that bladder response was immediately inhibitedafter 30 min of 10 Hz TNS, whereas it was excited at 50 Hz TNS. We also used the implantable stimulator to observe a change in duration of the prolonged post-stimulation inhibitory effect lasted after stimulation between individual animals. This study provides important evidence that can be used to understand the neurophysiological mechanisms underlying the bladder inhibitory response induced by TNS as well as the long-lasting prolonged poststimulation effect. |
| 키워드(Keyword) |
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| 파일첨부 |
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