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ÇѱÛÁ¦¸ñ(Korean Title) |
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¿µ¹®Á¦¸ñ(English Title) |
Development and Effectiveness Evaluation of implantable posterior tibial nerve stimulator for treatment of overactive bladder |
ÀúÀÚ(Author) |
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Eunmi Choi
Jaesoon Joo
Bonghee Lim
Kyusung Lee
Eunkyoung Park
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¿ø¹®¼ö·Ïó(Citation) |
VOL 45 NO. 01 PP. 2460 ~ 2463 (2022. 06) |
Çѱ۳»¿ë (Korean Abstract) |
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¿µ¹®³»¿ë (English Abstract) |
Tibial nerve stimulation (TNS) is one of the neuromodulation methods used to treat an overactive bladder (OAB). However, the treatment mechanism is not accurately understood owing to significant differences in the results obtained from animal and clinical studies. This, this study was aimed to confirm the response of bladder activity to the different stimulation frequencies and to observe the duration of prolonged post-stimulation inhibitory effects following TNS. This study usedunanesthetized rats to provide a closer approximation of the clinical setting and evaluated the changed in bladder activity in response to 30 min of TNS at different frequencies. Moreover, we observed the long-term changes of poststimulation inhibitory effects. Our results showed that bladder response was immediately inhibitedafter 30 min of 10 Hz TNS, whereas it was excited at 50 Hz TNS. We also used the implantable stimulator to observe a change in duration of the prolonged post-stimulation inhibitory effect lasted after stimulation between individual animals. This study provides important evidence that can be used to understand the neurophysiological mechanisms underlying the bladder inhibitory response induced by TNS as well as the long-lasting prolonged poststimulation effect. |
Å°¿öµå(Keyword) |
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