ÇѱÛÁ¦¸ñ(Korean Title) |
Semliki Forest Virus °¨¿°Àº ´º·±ÀÇ Å»¼öÃʸ¦ À¯¹ßÇÑ´Ù |
¿µ¹®Á¦¸ñ(English Title) |
Infection of Semliki Forest Virus Induces Demyelination of Neuron |
ÀúÀÚ(Author) |
±èÇöÁÖ
»ç¿µÈñ
È«¼º°©
Hyun Joo Kim
Young-Hee Sa
Seong-Karp Hong
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¿ø¹®¼ö·Ïó(Citation) |
VOL 21 NO. 01 PP. 0714 ~ 0717 (2017. 06) |
Çѱ۳»¿ë (Korean Abstract) |
½´¹Ý¼¼Æ÷¿Í ´º·± ¼¼Æ÷°¡ ÁãÀÇ ¹è¾ÆÀÇ Ã´¼ö½Å°æÀý·Î ºÎÅÍ °¢°¢ in vitro¿¡¼ ºÐ¸®µÇ¾ú´Ù. ¹è¾çµÈ ½´¹Ý¼¼Æ÷¿Í ´º·± ¼¼Æ÷´Â µ¿ÀÏÇÑ ÆòÆÇÁ¢½Ã¿¡¼ °øµ¿¹è¾ç µÇ¾ú´Ù. ÀÌµé ¼¼Æ÷µéÀº ¶§¼öÃÊÈ°¡ ÁøÇàµÇ¾ú´Ù. ÀÌ·¸°Ô ¼öÃÊÈµÈ °øµ¿ ¹è¾çÀº Semliki forest virus¿¡ ÀÇÇØ °¨¿°µÇ¾ú°í ±× ¶§ Å»¼öÃÊÈ °úÁ¤À» À¯¹ß½ÃÄ×´Ù. ¿ì¸®´Â ¼öÃÊÈµÈ ´º·±¿¡ Á¸ÀçÇÏ´Â peripheral myelin protein 22ÀÇ Ç×ü¸¦ ÀÌ¿ëÇÏ¿© ¼öÃÊÈ °úÁ¤°ú Å»¼öÃÊÈ °úÁ¤À» È®ÀÎÇÏ¿´´Ù.
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¿µ¹®³»¿ë (English Abstract) |
Schwann cells and Neuronal cells were isolated from dorsal root ganglion (DRG) in embryos of rat in vitro respectively. The cultured Schwann cells and cultured neuronal cells, respectively were co-cultured in a same plate. These cells were performed accomplishment of myelination. This myelinated co-culture system was infected by Semliki forest virus and then induced demyelination processing in this myelinated co-culture. We identified myelination and demyelination processing using antibody of peripheral myelin protein 22 (PMP 22) meaning presence of myelinated neuron.
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Å°¿öµå(Keyword) |
demyelination
myelination
peripheral myelin protein 22
Semliki forest virus
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