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Ȩ Ȩ > ¿¬±¸¹®Çå > Çмú´ëȸ ÇÁ·Î½Ãµù > Çѱ¹Á¤º¸Åë½ÅÇÐȸ Çмú´ëȸ > 2017³â Ãá°èÇмú´ëȸ

2017³â Ãá°èÇмú´ëȸ

Current Result Document : 8 / 27 ÀÌÀü°Ç ÀÌÀü°Ç   ´ÙÀ½°Ç ´ÙÀ½°Ç

ÇѱÛÁ¦¸ñ(Korean Title) Semliki Forest Virus °¨¿°Àº ´º·±ÀÇ Å»¼öÃʸ¦ À¯¹ßÇÑ´Ù
¿µ¹®Á¦¸ñ(English Title) Infection of Semliki Forest Virus Induces Demyelination of Neuron
ÀúÀÚ(Author) ±èÇöÁÖ   »ç¿µÈñ   È«¼º°©   Hyun Joo Kim   Young-Hee Sa   Seong-Karp Hong  
¿ø¹®¼ö·Ïó(Citation) VOL 21 NO. 01 PP. 0714 ~ 0717 (2017. 06)
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(Korean Abstract)
½´¹Ý¼¼Æ÷¿Í ´º·± ¼¼Æ÷°¡ ÁãÀÇ ¹è¾ÆÀÇ Ã´¼ö½Å°æÀý·Î ºÎÅÍ °¢°¢ in vitro¿¡¼­ ºÐ¸®µÇ¾ú´Ù. ¹è¾çµÈ ½´¹Ý¼¼Æ÷¿Í ´º·± ¼¼Æ÷´Â µ¿ÀÏÇÑ ÆòÆÇÁ¢½Ã¿¡¼­ °øµ¿¹è¾ç µÇ¾ú´Ù. ÀÌµé ¼¼Æ÷µéÀº ¶§¼öÃÊÈ­°¡ ÁøÇàµÇ¾ú´Ù. ÀÌ·¸°Ô ¼öÃÊÈ­µÈ °øµ¿ ¹è¾çÀº Semliki forest virus¿¡ ÀÇÇØ °¨¿°µÇ¾ú°í ±× ¶§ Å»¼öÃÊÈ­ °úÁ¤À» À¯¹ß½ÃÄ×´Ù. ¿ì¸®´Â ¼öÃÊÈ­µÈ ´º·±¿¡ Á¸ÀçÇÏ´Â peripheral myelin protein 22ÀÇ Ç×ü¸¦ ÀÌ¿ëÇÏ¿© ¼öÃÊÈ­ °úÁ¤°ú Å»¼öÃÊÈ­ °úÁ¤À» È®ÀÎÇÏ¿´´Ù.
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(English Abstract)
Schwann cells and Neuronal cells were isolated from dorsal root ganglion (DRG) in embryos of rat in vitro respectively. The cultured Schwann cells and cultured neuronal cells, respectively were co-cultured in a same plate. These cells were performed accomplishment of myelination. This myelinated co-culture system was infected by Semliki forest virus and then induced demyelination processing in this myelinated co-culture. We identified myelination and demyelination processing using antibody of peripheral myelin protein 22 (PMP 22) meaning presence of myelinated neuron.
Å°¿öµå(Keyword) demyelination   myelination   peripheral myelin protein 22   Semliki forest virus  
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