µ¥ÀÌÅͺ£À̽º ¿¬±¸È¸Áö(SIGDB)
ÇѱÛÁ¦¸ñ(Korean Title) |
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¿µ¹®Á¦¸ñ(English Title) |
A survey of sequence alignment algorithms for next-generation sequencing read |
ÀúÀÚ(Author) |
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Yunku Yeu
Chihyun Park
Jaegyoon Ahn
Minseo Park
Pankyu Kim
Sanghyun Park
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¿ø¹®¼ö·Ïó(Citation) |
VOL 28 NO. 01 PP. 0033 ~ 0051 (2012. 04) |
Çѱ۳»¿ë (Korean Abstract) |
¼¿ Á¤·Ä ¾Ë°í¸®ÁòÀº À¯ÀüÇп¡¼ ³Î¸® »ç¿ëµÇ´Â µµ±¸ Áß Çϳª´Ù. Â÷¼¼´ë ½ÃÄö½Ì ±â¼úÀÌ ¹ß´ÞÇÔ¿¡ µû¶ó ³ôÀº 󸮷®À» °®´Â ¿°±â ¼¿ Á¤·Ä ¾Ë°í¸®ÁòÀÌ ´Ù¼ö °³¹ßµÇ¾ú´Ù. Â÷¼¼´ë ½ÃÄö½Ì ±â¼úÀ» À§ÇÑ ¼¿ Á¤·Ä ¾Ë°í¸®ÁòÀº Å©°Ô Çؽà ±â¹Ý ¾Ë°í¸®Áò°ú BWT ±â¹Ý ¾Ë°í¸®ÁòÀ¸·Î ±¸ºÐÇÒ ¼ö ÀÖ´Ù. º» ³í¹®Àº Çؽà ±â¹Ý ¾Ë°í¸®Áò°ú BWT ±â¹Ý ¾Ë°í¸®ÁòÀÇ ´ëÇ¥ ¿¬±¸µéÀ» ÀÚ¼¼È÷ ¼³¸íÇÏ°í, ½Ã¹Ä·¹ÀÌ¼Ç µ¥ÀÌÅ͸¦ ÀÌ¿ëÇÏ¿© µÎ Ä«Å×°í¸®ÀÇ ¼º´ÉÀ» ºñ±³ ÇÏ¿´´Ù. Çؽà ±â¹Ý ¾Ë°í¸®ÁòÀº ´ÜÀÏ ¿°±â º¯ÀÌ°¡ ¸¹Àº µ¥ÀÌÅÍ ¼Â¿¡¼ ´õ ¸¹Àº ¸®µå¸¦ ¼º°øÀûÀ¸·Î Á¤·ÄÇßÀ¸¸ç, BWT ±â¹Ý ¾Ë°í¸®ÁòÀº º¯ÀÌ°¡ ÀûÀº µ¥ÀÌÅÍ ¼Â¿¡¼ µ¿µîÇÑ ¼öÁØÀÇ Á¤È®µµ¸¦ °¡Áö¸é¼µµ ´õ ºü¸¥ ó¸® ¼Óµµ¸¦ ³ªÅ¸³Â´Ù.
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¿µ¹®³»¿ë (English Abstract) |
Sequence alignment is one of the popular tools for genomics. A number of sequence alignment tools have been developed to support Next-Generation sequencing(NGS) read. Sequence alignment tools for NGS read can be classified into two major categories, hash-based and BWT-based. In this paper, we describe representative tools of those categories, and benchmark alignment tools using simulated dataset. As a result, the hash-based tools aligned more reads than the BWT-based tools in high mutation rate. The BWT-based tools showed faster alignment speed than the hash-based tools with equivalent accuracy in low mutation rate.
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Å°¿öµå(Keyword) |
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Â÷¼¼´ë ½ÃÄö½Ì
Sequence alignment
Next-Generation Sequencing
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