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Ȩ Ȩ > ¿¬±¸¹®Çå > ±¹³» ³í¹®Áö > Çѱ¹Á¤º¸°úÇÐȸ ³í¹®Áö > Á¤º¸°úÇÐȸ³í¹®Áö (Journal of KIISE)

Á¤º¸°úÇÐȸ³í¹®Áö (Journal of KIISE)

Current Result Document :

ÇѱÛÁ¦¸ñ(Korean Title) ´ëÀå Á¾¾ç ºÐ·ù¸¦ À§ÇÑ »ù ±¸Á¶¹° ÀÚµ¿ ºÐÇÒ ¾Ë°í¸®Áò
¿µ¹®Á¦¸ñ(English Title) An Automatic Segmentation Algorithm for Colonic Glandular Lesions
ÀúÀÚ(Author) Á¶¹Ì°æ   ÀÌÇý°æ   Á¶È¯±Ô   Migyung Cho   Hyekyung Lee   Hwan Gue Cho  
¿ø¹®¼ö·Ïó(Citation) VOL 45 NO. 06 PP. 0554 ~ 0563 (2018. 06)
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(Korean Abstract)
´ëÀåÀÇ ¼±Á¾ ¹× ¼±¾ÏÀº °¡Àå ÈçÇÑ Á¾¾ç Áß Çϳª·Î ÁÖ·Î »ù ±¸Á¶¹°ÀÇ ±¸Á¶Àû ¿Ü°ü°ú ¼¼Æ÷ÇüÅÂÀÇ º¯È­¿¡ ±âÃÊÇÏ¿© Áø´ÜÀÌ ÀÌ·ç¾îÁø´Ù. ÀÌ·¯ÇÑ Áø´ÜÀº °¢ º´¸®ÀÇ»çÀÇ ÁÖ°ü°ú °´°ü¿¡ ÀÇÇϸç Á» ´õ ³ªÀº °´°üÀû °á°ú¿Í ÀçÇö¼ºÀ» À§ÇØ »ù ±¸Á¶¹°¿¡¼­ ÀÇ¹Ì Àִ Ư¡À» ÃßÃâÇÏ°íÀÚ ÇÏ´Â ¸¹Àº ¿¬±¸°¡ ÁøÇà ÁßÀÌ´Ù. »ù ±¸Á¶¹°ÀÇ Æ¯Â¡À» ÃßÃâÇϱâ À§ÇØ »ù ±¸Á¶¹°À» ¼öµ¿ÀûÀ¸·Î ºÐÇÒÇÏ´Â °ÍÀº ³ëµ¿Áý¾àÀûÀÎ ÀÛ¾÷À¸·Î ¸¹Àº ½Ã°£°ú ¶§·Î´Â ¾î·Á¿òÀÌ ¹ß»ýÇÑ´Ù. ÀÌ·¯ÇÑ ¹®Á¦Á¡µé·Î ÀÎÇØ »ù ±¸Á¶¹°ÀÇ ÇüŸ¦ Á¤·®È­Çϱâ À§ÇÑ ÀÚµ¿È­µÈ Á¢±Ù¹ýÀÌ ÇÊ¿äÇÏ´Ù. º» ³í¹®¿¡¼­´Â »ù ±¸Á¶¹°ÀÇ ÇüŸ¦ Á¤·®È­Çϱâ À§ÇØ Á¤»ó°ú º¯ÇüÀÌ ½ÃÀÛµÈ Ãʱ⠴ܰèÀÇ »ù ±¸Á¶¹°À» ºÐÇÒÇϱâ À§ÇÑ ¾Ë°í¸®ÁòÀ» °³¹ßÇÏ¿´´Ù. ¾Ë°í¸®ÁòÀº k-means Ŭ·¯½ºÅ͸µ¿¡ ÀÇÇØ ¾òÀº ÀûÀÀÀû ÀÓ°è°ªÀ» ¼øÂ÷ÀûÀ¸·Î Àû¿ëÇÏ¿© ÀÌÁøÈ­ÀÛ¾÷°ú ÇÊÅ͸µ ÀÛ¾÷À» ¼öÇàÇÏ°í ±× °á°ú·Î ¾òÀº À̹ÌÁöÀÇ °æ°è¼±À» ÃßÃâÇÏ°í °áÇÕÇÏ¿© »ù ±¸Á¶¹°ÀÇ ¹Ù±ùÂÊ ¹æÇâ°ú ¾ÈÂÊ ¹æÇâ ¸ðµÎ¿¡¼­ »ù ±¸Á¶¹°À» ã¾Æ°¡´Â ¹æ½ÄÀ¸·Î ºÐÇÒÇÑ´Ù. Á¦¾ÈµÈ ¾Ë°í¸®ÁòÀ» º´¿ø¿¡¼­ »ç¿ëÇÏ´Â ¿µ»ó¿¡ Àû¿ëÇÑ °á°ú 95%ÀÌ»óÀÇ Á¤È®µµ¸¦ º¸¿©ÁÖ¾ú´Ù. ¶ÇÇÑ ·¹º§ ¼Â ±â¹Ý ¾Ë°í¸®Áò¿¡ ºñÇØ ¼öÇà¼Óµµ°¡ ÇöÀúÈ÷ ºü¸£¹Ç·Î ¸Å¿ì ½Ç¿ëÀûÀÎ ¾Ë°í¸®ÁòÀ̶ó°í ÇÒ ¼ö ÀÖ´Ù.
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(English Abstract)
Adenoma and adenocarcinoma of the colon are one of the most common tumors, and diagnoses are based mainly on the structural appearances and changes in cell morphology of the glandular structures. Each diagnosis is based on subjectivity and objectivity of each pathologist, and many studies are under way to extract meaningful features from the glandular structure for better objective results and reproducibility. Passive segmentation of glandular cells to extract structural features is a labor-intensive task performed over many hours and with some difficulties. These problems require an automated approach to quantify the shapes of glandular cells. In this paper, we have developed an algorithm for segmentation of glandular cells to quantify their shapes in the benign and initial stages of deformation signifying the onset of disease. The algorithm sequentially applies adaptive thresholds obtained by k-means clustering and obtains binary images by thresholding and filtering methods. We extract boundary information from binary images and combine several boundary information, and then we search for glandular cells, both in the outward direction and inward direction from the boundary information. Applying the proposed algorithm to clinical images showed more than 95% accuracy. In addition, it is a very practical algorithm because it is much faster than the level-set based algorithms.
Å°¿öµå(Keyword) ºÐÇÒ   »ù ±¸Á¶¹°   Á¾¾ç µî±Þ   µðÁöÅк´¸®   segmentation   glandular cell   tumor grading   digital pathology  
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