Á¤º¸°úÇÐȸ ÄÄÇ»ÆÃÀÇ ½ÇÁ¦ ³í¹®Áö (KIISE Transactions on Computing Practices)
Current Result Document :
ÇѱÛÁ¦¸ñ(Korean Title) |
»ý¹°ÇÐ ¹®Çå µ¥ÀÌÅÍÀÇ Á¦¸ñ°ú º»¹®À» ÀÌ¿ëÇÑ Áúº´ °ü·Ã À¯ÀüÀÚ Ãß·Ð ¹æ¹ý |
¿µ¹®Á¦¸ñ(English Title) |
Inferring Disease-related Genes using Title and Body in Biomedical Text |
ÀúÀÚ(Author) |
±èÁ¤¿ì
±èÇöÁø
¿©À±±¸
½Å¹Îö
¹Ú»óÇö
Jeongwoo Kim
Hyunjin Kim
Yunku Yeo
Mincheol Shin
Sanghyun Park
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¿ø¹®¼ö·Ïó(Citation) |
VOL 23 NO. 01 PP. 0028 ~ 0036 (2017. 01) |
Çѱ۳»¿ë (Korean Abstract) |
1990³â´ë °Ô³ðÇÁ·ÎÁ§Æ® ÀÌÈÄ À¯ÀüÀÚ¿Í °ü·ÃµÈ ¸¹Àº ¿¬±¸°¡ ÁøÇàµÇ°í ÀÖ´Ù. µ¥ÀÌÅÍ ÀúÀå ±â¼úÀÇ ¹ß´Þ·Î ¿¬±¸ÀÇ °á°ú¹°µéÀº ´Ù·®ÀÇ ¹®Çåµé·Î ±â·ÏµÇ°í ÀÖÀ¸¸ç, ÀÌ·¯ÇÑ ¹®ÇåµéÀº »õ·Î¿î »ý¹°ÇÐÀû °ü°èµéÀ» Ãß·ÐÇÏ´Â µ¥ÀÌÅÍ·Î À¯¿ëÇÏ°Ô »ç¿ëµÇ°í ÀÖ´Ù. ÀÌ·¯ÇÑ ÀÌÀ¯·Î º» ¿¬±¸¿¡¼´Â »ý¹°ÇÐ ¹®ÇåµéÀ» È°¿ëÇÏ¿© Áúº´°ú °ü·ÃÇÑ À¯ÀüÀÚ¸¦ Ãß·ÐÇÏ´Â ¹æ¹ý·Ð¿¡ ´ëÇؼ Á¦¾ÈÇÑ´Ù. ¹®ÇåµéÀ» Á¦¸ñ°ú º»¹®À¸·Î ±¸ºÐÇÏ°í, °¢ ¿µ¿ª¿¡¼ µîÀåÇÑ À¯ÀüÀÚµéÀ» ÃßÃâÇÑ´Ù. Á¦¸ñ ¿µ¿ª¿¡¼ ÃßÃâµÈ À¯ÀüÀÚ´Â Á᫐ À¯ÀüÀÚ·Î ±¸ºÐÇÏ°í, º»¹® ¿µ¿ª¿¡¼ ÃßÃâµÈ À¯ÀüÀÚ´Â Á¦¸ñ¿¡¼ ÃßÃâµÈ À¯ÀüÀÚ¿Í °ü°è¸¦ °®´Â ÁÖº¯ À¯ÀüÀÚ·Î ±¸ºÐÇÑ´Ù. ÀÌ·¯ÇÑ °úÁ¤À» °¢ ¹®Çå¿¡ Àû¿ëÇÏ¿©, Áö¿ª À¯ÀüÀÚ ³×Æ®¿öÅ©¸¦ ±¸ÃàÇÑ´Ù. ±¸ÃàµÈ Áö¿ª À¯ÀüÀÚ ³×Æ®¿öÅ©´Â ¸ðµÎ ¿¬°áÇÏ¿© Àü¿ª À¯ÀüÀÚ ³×Æ®¿öÅ©¸¦ ±¸ÃàÇÑ´Ù. ±¸ÃàÇÑ ³×Æ®¿öÅ©¸¦ ºÐ¼®ÇÏ¿© Áúº´ °ü·Ã À¯ÀüÀÚ¸¦ Ãß·ÐÇÏ¿´À¸¸ç, ºñ±³ ½ÇÇèÀ» ÅëÇØ Á¦¾ÈÇÏ´Â ¹æ¹ý·ÐÀÌ Áúº´ °ü·Ã À¯ÀüÀÚ¸¦ Ãß·ÐÇÏ´Â À¯¿ëÇÑ ¹æ¹ý·ÐÀÓÀ» ÀÔÁõÇÏ¿´´Ù.
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¿µ¹®³»¿ë (English Abstract) |
After the genome projects of the 90s, a vast number of gene studies have been stored in online databases. By using these databases, several biological relationships can be inferred. In this study, we proposed a method to infer disease-gene relationships using title and body in biomedical text. The title was used to extract hub genes from data in the literature; whereas, the body of the literature was used to extract sub genes that are related to hub genes. Through these steps, we were able to construct a local gene-network for each report in the literature. By integrating the local gene-networks, we then constructed a global gene-network. Subsequent analyses of the global gene-network allowed inference of disease-related genes with high rank. We validated the proposed method by comparing with previous methods. The results indicated that the proposed method is a meaningful approach to infer disease-related genes.
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Å°¿öµå(Keyword) |
À¯ÀüÀÚ
Áúº´
À¯ÀüÀÚ-Áúº´°ü°è
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À¯ÀüÀÚ³×Æ®¿öÅ©
gene
disease
disease-gene relationship
text-mining
gene network
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