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ÇѱÛÁ¦¸ñ(Korean Title) |
ÇÏÇ÷ΟÀÔ ÆäÀÌ¡ ¾Ë°í¸®Áò¿¡ °üÇÑ Á¶»ç¿¬±¸ |
¿µ¹®Á¦¸ñ(English Title) |
A Survey on Computational Methods for Haplotype Phasing |
ÀúÀÚ(Author) |
ÀÌÈ«¶õ
ÀÌÁ¦±Ù
À庴Ź
Ȳ±Ô¹é
½Å¼ö¿ë
Honglan Li
Je-Keun Rhee
Byoung-Tak Zhang
Kyu-Baek Hwang
Soo-Yong Shin
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¿ø¹®¼ö·Ïó(Citation) |
VOL 40 NO. 11 PP. 0663 ~ 0674 (2013. 11) |
Çѱ۳»¿ë (Korean Abstract) |
Àΰ£ À¯Àüü ¼¿ °áÁ¤ÀÌ °¡´ÉÇØ Áü¿¡ µû¶ó °³ÀÎ ¸ÂÃãÇü ÀÇÇÐÀ» À§ÇÑ °³ÀÎÀÇ À¯ÀüÀû ´ÙÇü¼ºÀ» ¹àÈ÷´Â ¿¬±¸°¡ ±¤¹üÀ§ÇÏ°Ô ÁøÇàµÇ°í ÀÖ´Ù. ƯÈ÷ ÃÖ±Ù µé¾î µ¿ÀÏ ¿°»öü º¹¼öÁÂÀ§¿¡¼ÀÇ ´ë¸³ÇüÁúÀ» °í·ÁÇÏ¿© ´ÜÀÏ¿°±â´ÙÇü¼º¿¡ ±â¹ÝÇÑ À¯Àüü ¼¿ ÇÏÇ÷ΟÀÔ(haplotype)À» »ý¼ºÇÏ´Â ÇÏÇ÷ΟÀÔ ÆäÀÌ¡(phasing) ºÐ¼®ÀÌ ÁÖ¸ñÀ» ¹Þ°í ÀÖ´Ù. ±âÁ¸¿¡´Â ÁÖ·Î ÀÛÀº ¹üÀ§ ³»¿¡¼ÀÇ ÇÏÇ÷ΟÀÔ ÆäÀÌ¡ ¿¬±¸°¡ ¼öÇàµÇ¾úÀ¸³ª, ÃÖ±Ù Â÷¼¼´ë ½ÃÄö½Ì ±â¼úÀÇ ±Þ°ÝÇÑ ºñ¿ë Ç϶ôÀ¸·Î ÀÎÇØ À¯Àüü Àüü¸¦ ´ë»óÀ¸·Î ÇÑ ÆäÀÌ¡ ¿¬±¸µµ ½ÃµµµÇ°í ÀÖ´Ù. º» ³í¹®¿¡¼´Â ÃÖ±Ù±îÁö Á¦½ÃµÈ ÇÏÇ÷ΟÀÔ ÆäÀÌ¡ ¾Ë°í¸®ÁòÀ» Á¶»çÇÏ°í ºÐ¼®Çϸç, ÇâÈÄ ¿¬±¸ ¹æÇâ¿¡ ´ëÇØ ¸ð»öÇØ º¸°íÀÚ ÇÑ´Ù.
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¿µ¹®³»¿ë (English Abstract) |
Based on the recent achievement of sequencing technologies, the research on the genetic variation have been highlighted for realizing personalized medicine. Since human genome consists of diploid, the approach to find haploid which is a combination of alleles at adjacent locations on the chromosome, called haplotype phasing studies have drawn attention. Haplotype phasing is the method to detect haplotype block based on heterogeneous single nucleotide polymorphisms (SNPs). Usually, the research has been widely applied in a small part of chromosome, but the recent research starts to focus on the phasing of whole genome, using next generation sequencing data. In this paper, we will review the computational methods for haplotype phasing, and then suggest the promising direction of the computational haplotype phasing approaches.
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Å°¿öµå(Keyword) |
ÇÏÇ÷ΟÀÔ
ÆäÀÌ¡
´ÜÀÏ¿°±â´ÙÇü¼º
Â÷¼¼´ë½ÃÄö½Ì
haplotype
phasing
single nucleotide polymorphism
next generation sequencing
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