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ÇѱÛÁ¦¸ñ(Korean Title) |
ÁøÈ¿¬»ê ±â¹Ý °èÃþÀû ÇÏÀÌÆÛ³×Æ®¿öÅ© ¸ðµ¨¿¡ ÀÇÇÑ ¾Ï ƯÀÌÀû microRNA-mRNA »óÈ£ÀÛ¿ë Ž»ö |
¿µ¹®Á¦¸ñ(English Title) |
Exploring Cancer-Specific microRNA-mRNA Interactions by Evolutionary Layered Hypernetwork Models |
ÀúÀÚ(Author) |
±è¼öÁø
ÇÏÁ¤¿ì
À庴Ź
Soo-Jin Kim
Jung-Woo Ha
Byoung-Tak Zhang
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¿ø¹®¼ö·Ïó(Citation) |
VOL 16 NO. 10 PP. 0980 ~ 0984 (2010. 10) |
Çѱ۳»¿ë (Korean Abstract) |
microRNA (miRNA)¿Í mRNA Á¶Àý »óÈ£ÀÛ¿ë Ž»öÀº ´Ù¾çÇÑ »ý¹°ÇÐÀû Çö»ó¿¡ ÀÖ¾î »õ·Î¿î ½Ã¾ß¸¦ Á¦°øÇØ ÁÙ ¼ö ÀÖ´Ù. ÃÖ±Ù »ý¹°ÇÐÀû ÇÁ·Î¼¼½º¿¡¼ miRNA´Â À¯ÀüÀÚ ¹ßÇöÀ» Á¦¾îÇÏ°í ¼¼Æ÷¸¦ ±â´ÉÀûÀ¸·Î Á¶ÀýÇÏ´Â Áß¿äÇÑ ¿ªÇÒÀ» ÇÏ´Â ¿ä¼Ò·Î ¹àÇôÁ³´Ù. ÀÌ¿¡ º¹ÀâÇÑ »ý¹°ÇÐ ½Ã½ºÅÛ¿¡¼ miRNAÀÇ ±â´ÉÀû È°µ¿À» ÀÌÇØÇϱâ À§Çؼ´Â miRNA¿Í mRNA°£ »óÈ£ÀÛ¿ë ºÐ¼®Àº ÇʼöÀûÀÌ´Ù. ±×·¯³ª ¾ÆÁ÷±îÁö º¹ÀâÇÑ miRNA¿Í mRNA°£ »óÈ£ÀÛ¿ë °ü°è¸¦ Ãß·ÐÇÏ´Â °ÍÀº ¾î·Á¿î ¹®Á¦À̱⠶§¹®¿¡ ¸¹Àº ¿¬±¸ÀÚµéÀÌ ½ÇÇèÀû, Àü»êÇÐÀû Á¢±Ù ¹æ¹ýÀ» Á¦¾ÈÇϸç È°¹ßÇÑ ¿¬±¸¸¦ ÁøÇàÇÏ°í ÀÖ´Ù. º» ³í¹®¿¡¼´Â ÀÌÁ¾ÀÇ ¹ßÇö µ¥ÀÌÅͷκÎÅÍ ±â´ÉÀûÀ¸·Î »óÈ£ÀÛ¿ëÇÏ´Â miRNA-mRNA Á¶ÇÕÀ» Ž»öÇϱâ À§ÇÑ ÁøÈ¿¬»ê ±â¹ÝÀÇ »õ·Î¿î ÇÏÀÌÆÛ³×Æ®¿öÅ© ¸ðµ¨À» Á¦¾ÈÇÑ´Ù. ÀÌ¿¡ ½ÇÇè°á°ú·Î Á¦¾ÈÇÏ´Â ¹æ¹ýÀ» Àΰ£ ¾Ï °ü·Ã miRNA¿Í mRNA ¹ßÇö µ¥ÀÌÅÍ¿¡ Àû¿ëÇÏ¿© ¾Ï ƯÀÌÀû miRNA-mRNA »óÈ£ÀÛ¿ë ÁýÇÕÀ» Ž»öÇÏ°í ¹ß°ßÇÑ miRNA-mRNA »óÈ£ÀÛ¿ë °ü°è°¡ »ý¹°ÇÐÀûÀ¸·Î À¯ÀÇÇÔÀ» Á¦½ÃÇÑ´Ù. |
¿µ¹®³»¿ë (English Abstract) |
Exploring microRNA (miRNA) and mRNA regulatory interactions may give new insights into diverse biological phenomena. Recently, miRNAs have been discovered as important regulators that play a major role in various cellular processes. Therefore, it is essential to identify functional interactions between miRNAs and mRNAs for understanding the context- dependent activities of miRNAs in complex biological systems. While elucidating complex miRNA-mRNA interactions has been studied with experimental and computational approaches, it is still difficult to infer miRNA-mRNA regulatory modules. Here we present a novel method, termed layered hypernetworks (LHNs), for identifying functional miRNA- mRNA interactions from heterogeneous expression data. In experiments, we apply the LHN model to miRNA and mRNA expression profiles on multiple cancers. The proposed method identifies cancer-specific miRNA-mRNA interactions. We show the biological significance of the discovered miRNA- mRNA interactions. |
Å°¿öµå(Keyword) |
±â°èÇнÀ
ÁøÈ¿¬»ê
»ý¹°Á¤º¸ÇÐ
miRNA-mRNA »óÈ£ÀÛ¿ë
Machine Learning
Evolutionary Learning
Bioinformatics
miRNA-mRNA Interactions
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ÆÄÀÏ÷ºÎ |
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