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ÇѱÛÁ¦¸ñ(Korean Title) |
SNP Á¶ÇÕ ÀÎÀÚµéÀÇ ÁøÈÀû ÇнÀ ¹æ¹ý ±â¹Ý Áúº´ °ü·Ã º¹ÇÕÀû À§Çè ¿äÀÎ ÃßÃâ |
¿µ¹®Á¦¸ñ(English Title) |
Identifying Compound Risk Factors of Disease by Evolutionary Learning of SNP Combinatorial Features |
ÀúÀÚ(Author) |
ÀÌÁ¦±Ù
ÇÏÁ¤¿ì
¹è¼³Èñ
±è¼öÁø
À̹μö
¹Ú±ÙÁØ
À庴Ź
Jekeun Rhee
Jungwoo Ha
Seolhui Bae
Soojin Kim
Min Su Lee
Keunjoon Park
Byoungtak Zhang
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¿ø¹®¼ö·Ïó(Citation) |
VOL 15 NO. 12 PP. 0928 ~ 0932 (2009. 12) |
Çѱ۳»¿ë (Korean Abstract) |
»ýü ³»¿¡¼ Áúº´ ¹ß»ýÀº ´Ù¾çÇÑ ¿äÀεéÀÇ º¹ÇÕÀûÀÎ ÀÛ¿ë¿¡ ÀÇÇØ ¹ß»ýÇÑ´Ù. ÇÏÁö¸¸, ´ëºÎºÐÀÇ Áúº´ °ü·Ã ¿øÀÎÀ» ¹ß°ßÇÏ°íÀÚÇÏ´Â ¿¬±¸µé¿¡¼´Â ¿©·¯ ¿äÀεéÀÇ ´Ù¾çÇÑ Á¶ÇÕµéÀ» º¹ÇÕÀûÀ¸·Î °í·ÁÇÏ¿© ºÐ¼®Çϱ⿡´Â ÇÑ°è°¡ ÀÖ´Â °æ¿ì°¡ ¸¹´Ù. ´Ü ÇϳªÀÇ Áúº´ °ü·Ã ¿äÀεéÀ» ã´Â °Í¿¡ ±×Ä¡°í ÀÖ´Ù. º» ¿¬±¸¿¡¼´Â À¯Àüü Á¤º¸°ú ÀÓ»ó Á¤º¸¸¦ ÀÌ¿ëÇÏ¿© Áúº´ ºÐ·ù ¸ðµ¨ ±â¹Ý ÀÎÀÚ Á¶ÇÕµéÀÇ ÁøÈÀû ÇнÀ ¹æ¹ýÀ» Á¦¾ÈÇÑ´Ù. ÀÌ ¹æ¹ýÀ» ÀÌ¿ëÇÏ¿© º» ¿¬±¸¿¡¼´Â Áúº´ °ü·Ã ÁÖ¿ä ÀÎÀÚ¸¦ ã°í, À̸¦ ½Ã°¢ÈÇÒ ¼ö ÀÖ´Â ½Ã½ºÅÛÀ» ¸¸µå´Â °ÍÀ» ¸ñÀûÀ¸·Î ÇÑ´Ù. º» ¿¬±¸¸¦ ÅëÇØ Á¤È®µµ ³ôÀº ´ç´¢º´ ȯÀÚ±º ºÐ·ù ¸ðµ¨À» ¸¸µé°í, ´ç´¢º´ ¹ß»ý¿¡ Áß¿äÇÑ ¿µÇâÀ» ¹ÌÄ¡´Â ÀÎÀÚµéÀÇ Á¶ÇÕÀ» ãÀ» ¼ö ÀÖ¾ú´Ù. ¶ÇÇÑ »ý¹°ÇÐÀûÀÎ ºÐ¼®À» ÅëÇØ º» ¿¬±¸¿¡¼ ãÀº ÀÎÀÚµéÀÇ Á¶ÇÕÀÌ ½ÇÁ¦·Îµµ ´ç´¢º´ ¹ß»ý¿¡ ¿µÇâÀ» ¹ÌÄ¡´Â ÀÎÀÚ°¡ µÉ ¼ö ÀÖÀ½À» È®ÀÎÇÏ°í, ƯÈ÷ °¢ ÀÎÀÚµéÀÌ Çϳª¾¿ Á¸ÀçÇÒ ¶§º¸´Ù, Á¶ÇÕÀ¸·Î Á¸ÀçÇÒ °æ¿ì ´ç´¢º´ ¹ß»ý °¡´É¼ºÀÌ ³ô¾ÆÁú ¼ö ÀÖÀ½À» È®ÀÎÇÒ ¼ö ÀÖ¾ú´Ù. |
¿µ¹®³»¿ë (English Abstract) |
Most diseases are caused by complex processes of various factors. Although previous researches have tried to identify the causes of the disease, there are still lots of limitations to clarify the complex factors.
Here, we present a disease classification model based on an evolutionary learning approach of combinatorial features using the datasets from the genetics and cohort studies. We implemented a system for finding the combinatorial risk factors and visualizing the results. Our results show that the proposed method not only improves classification accuracy but also identifies biologically meaningful sets of risk factors. |
Å°¿öµå(Keyword) |
±â°èÇнÀ
ÁøÈ¿¬»ê
»ý¹°Á¤º¸ÇÐ
ÀÎÀÚÃßÃâ
Machine Learning
Evolutionary Learning
Bioinformatics
Feature Selection
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ÆÄÀÏ÷ºÎ |
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