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ÇѱÛÁ¦¸ñ(Korean Title) |
ÁýÇÕ °áÇÕ°ú ½Å°æ¸ÁÀ» ÀÌ¿ëÇÑ º¹ÇÕÁúȯÀÇ ¿¹Ãø |
¿µ¹®Á¦¸ñ(English Title) |
A Prediction Model for Complex Diseases using Set Association & Artificial Neural Network |
ÀúÀÚ(Author) |
ÃÖÇöÁÖ
±è½ÂÇö
À§±Ô¹ü
Hyunjoo Choi
Kim Seunghyun
Kyubum Wee
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¿ø¹®¼ö·Ïó(Citation) |
VOL 15-B NO. 04 PP. 0323 ~ 0330 (2008. 08) |
Çѱ۳»¿ë (Korean Abstract) |
º¹ÇÕÁúȯÀº ´Ù¼öÀÇ À¯ÀüÀÚµéÀÌ »óÈ£ÀÛ¿ëÇÏ¿© À¯¹ßµÇ´Â Áúº´À¸·Î¼, ¿©·¯ À¯ÀüÀÚµéÀÌ °ü¿©ÇÑ´Ù´Â º¹À⼺ ¶§¹®¿¡ ÀüÅëÀûÀÎ ºÐ¼® ¹æ¹ýÀ» Àû¿ë Çϴµ¥ ÇÑ°è°¡ ÀÖ´Ù. ÃÖ±Ù¿¡´Â ±â°èÇнÀ ±â¹ýÀ» ÀÌ¿ëÇÑ »õ·Î¿î ºÐ¼® ¹æ¹ýµéÀÌ Á¦¾ÈµÇ°í ÀÖ´Ù. ½Å°æ¸ÁÀº ÀÌó·³ º¹ÀâÇÑ µ¥ÀÌÅÍ¿¡¼ ÀÏÁ¤ÇÑ ÆÐÅÏÀ» ã¾Æ À̸¦ ºÐ·ùÇϴµ¥ ÀûÇÕÇÑ ¸ðµ¨ÀÌ´Ù. ±×·¯³ª ´Ù·®ÀÇ µ¥ÀÌÅÍ°¡ ÀÔ·ÂÀ¸·Î µé¾î¿À´Â °æ¿ì¿¡ ÇнÀ¿¡ ¿À·£ ½Ã°£ÀÌ °É¸®°í ÆÐÅÏÀ» ã±â°¡ ¾î·Á¿öÁö´Â ´ÜÁ¡ÀÌ ÀÖ´Ù. º» ¿¬±¸¿¡¼´Â ´Ù·®ÀÇ SNP µ¥ÀÌÅͷκÎÅÍ Áúº´¿¡ ¿¬°üµÈ ¼Ò¼öÀÇ Áß¿ä SNPÀ» ã±â À§ÇÑ Åë°èÇÐÀûÀÎ ¹æ¹ýÀÎ ÁýÇÕ°áÇÕ(set association)°ú ½Å°æ¸ÁÀ» °áÇÕÇÑ ¸ðµ¨À» Á¦½ÃÇÑ´Ù. ÀÌ ¸ðµ¨À» õ½Ä °ü·Ã SNP µ¥ÀÌÅÍ¿¡ Àû¿ëÇÏ¿© õ½Ä ¹ßº´ ¿©ºÎ¸¦ ¿¹ÃøÇÑ °á°ú, ½Å°æ¸Á¸¸ »ç¿ëÇßÀ» ¶§º¸´Ù ½ÇÇà ½Ã°£µµ ºü¸£°í ¿¹Ãø Á¤È®µµµµ ³ô¾Ò´Ù. ÀÌ ¸ðµ¨Àº ´Ù¸¥ º¹ÇÕÁúȯÀÇ ¿¹Ãø¿¡µµ È¿°úÀûÀ¸·Î »ç¿ëÇÒ ¼ö ÀÖÀ» °ÍÀ¸·Î ±â´ëÇÑ´Ù. |
¿µ¹®³»¿ë (English Abstract) |
Since complex diseases are caused by interactions of multiple genes, traditional statistical methods are limited in its power to predict the onset of a complex disease. Recently new approaches using machine learning techniques are introduced. Neural nets are a suitable model to find patterns in complex data. When large amount of data are fed into a neural net, however, it takes a long time for learning and finding patterns. In this study we suggest a new model that combines the set association, which is a statistical technique to find important SNPs associated with complex diseases, and neural network. We experiment with SNP data related to asthma to test the effectiveness of our model. Our model shows higher prediction accuracy and shorter execution time than neural net only. We expect our model can be used effectively to predict the onset of other complex diseases. |
Å°¿öµå(Keyword) |
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ÁýÇÕ °áÇÕ
´ÜÀÏ¿°±â´ÙÇü¼º
º¹ÇÕÁúȯ
»ý¹°Á¤º¸ÇÐ
Artificial Neural Network
Set Association
Single Nucleotide Polymorphism(SNP)
Complex Disease
Bioinformatics
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