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ÇѱÛÁ¦¸ñ(Korean Title) |
´ÙÁ¾ÀÇ À¯Àüü·ÎºÎÅÍ Å½ÁöµÈ Ortholog ±ºÁý¿¡ ´ëÇÑ ºÐ¼® |
¿µ¹®Á¦¸ñ(English Title) |
An Analysis of Ortholog Clusters Detected fromMultiple Genomes |
ÀúÀÚ(Author) |
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Sun Shin Kim
Jeongsu Oh
Bum Ju Lee
Tae Kyung Kim
Kwang Su Jung
Chung Sei Rhee
Young Chang Kim
Wan Sup Cho
Keun Ho Ryu
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¿ø¹®¼ö·Ïó(Citation) |
VOL 35 NO. 02 PP. 0125 ~ 0131 (2008. 04) |
Çѱ۳»¿ë (Korean Abstract) |
»õ·Î¿î À¯Àüü ÁÖ¼®´Þ±â¿Í À¯Àüü ÁøÈ¿¡ ´ëÇÑ ¿¬±¸¸¦ À§Çؼ ¿Ã¼Ò·Î±×(Ortholog)¸¦ ŽÁöÇÏ´Â ÀÏÀº ¸Å¿ì À¯¿ëÇÏ´Ù. ÀÌÀü¿¡ Á¦¾ÈÇÑ ¿¬±¸¿¡¼, ¿ì¸®´Â ¿©·¯ Á¾ÀÇ À¯Àüü·ÎºÎÅÍ ¿Ã¼Ò·Î±× Ŭ·¯½ºÅ͸¦ ÀÚµ¿ÀûÀ¸·Î ±¸ÃàÇÏ´Â ¹æ¹ýÀ» Á¦¾ÈÇÏ¿´´Ù. ÀÌ ¹æ¹ýÀº ´ÜÁö µÎ Á¾ÀÇ °á°ú¸¦ »ý¼ºÇÏ´Â InParanoid¸¦ ¿©·¯ Á¾À¸·Î È®ÀåÇÏ°í ÀÌ¿Í µ¿ÀÏÇÑ ÁúÀ» °¡Áø °á°ú¸¦ »êÃâÇÑ´Ù. ÇÑÆí, »õ·Ó°Ô ¼¿ÀÌ ¹àÇôÁø À¯ÀüÀÚÀÇ ±â´ÉÀ» º¸´Ù Á¤È®È÷ ¿¹ÃøÇϱâ À§ÇØ, Æз²·Î±×(Paralog)°¡ °¡±ÞÀû Àû°Ô Æ÷ÇԵǴ ¿Ã¼Ò·Î±× Ŭ·¯½ºÅ͸¦ ±¸ÃàÇÏ´Â °ÍÀÌ Áß¿äÇÑ ¹®Á¦°¡ µÉ ¼ö ÀÖ´Ù. ÀÌ ³í¹®¿¡¼, ¿ì¸®´Â ÀÓ°è°ªÀ» »ç¿ëÇÏ¿© º¸´Ù ¼ø¼öÇÑ ¿Ã¼Ò·Î±× Ŭ·¯½ºÅ͸¦ ±¸ÃàÇÏ´Â ¹æ¹ý¿¡ ´ëÇÏ¿© Á¶»çÇÏ¿´´Ù. ¿ì¸®´Â 20°³ÀÇ ¿øÇÙ»ý¹°ÀÇ µ¥ÀÌŸ¼ÂÀ¸·ÎºÎÅÍ ¿Ã¼Ò·Î±× Ŭ·¯½ºÅ͸¦ ±¸ÃàÇÏ¿´´Ù. ¿ì¸®ÀÇ ¿Ã¼Ò·Î±× Ŭ·¯½ºÅ͸¦ COG(Clusters of Orthologous Group) ¹× KO(Kegg Orthology)¿Í ºñ±³ÇÏ¿´À» ¶§, ¾à 90%ÀÇ À¯»çµµ¸¦ °¡Áö¸ç ÀÓ°è°ªÀÇ Áõ°¡¿Í ´õºÒ¾î Áõ°¡ÇÏ´Â °æÇâÀÌ ÀÖ´Ù.
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¿µ¹®³»¿ë (English Abstract) |
It is very useful to predict orthologs for new genome annotation and research on genome evolution. We showed that the previous work can be extended to construct OCs(Ortholog Clusters) automatically from multiple complete-genomes. The proposed method also has the quality of production of InParanoid, which produces orthologs from just two genomes. On the other hand, in order to predict more exactly the function of a newly sequenced gene it can be an important issue to prevent unwanted inclusion of paralogs into the OCs. We have, here, investigated how well it is possible to construct a functionally purer OCs with score cut-offs. Our OCs were generated from the datasets of 20 procaryotes. The similarity with both COG(Clusters of Orthologous Group) and KO(Kegg Orthology) against our OCs has about 90% and inclines to increase with the growth of score cut-offs. |
Å°¿öµå(Keyword) |
¿Ã¼Ò·Î±×(ortholog)
À¯Àüü
InParanoid
Æз²·Î±×(paralog)
COG
¹× KO
ortholog
genome
InParanoid
paralog
COG
and KO
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