Á¤º¸Ã³¸®ÇÐȸ ³í¹®Áö B
Current Result Document :
ÇѱÛÁ¦¸ñ(Korean Title) |
ÅÛÇø´ Á¤ÇÕ¹ýÀ» ÀÌ¿ëÇÑ ¿Â-¿ÀÇÁ ÇüÅ DNA ĨÀÇ Å½»öÀÚ ±¸ºÐ |
¿µ¹®Á¦¸ñ(English Title) |
Probe Classification of an On-Off Type DNA Chip Using Template Matching Method |
ÀúÀÚ(Author) |
À¯¹®È£
|
¿ø¹®¼ö·Ïó(Citation) |
VOL 13-B NO. 06 PP. 0579 ~ 0584 (2006. 12) |
Çѱ۳»¿ë (Korean Abstract) |
º» ¿¬±¸´Â Ä«¿îÆà Á¤ÇÕµµ¶ó ºÒ¸®´Â, ºñ¼±Çü Á¤ÇÕµµ¸¦ ôµµ·Î ÇÏ´Â ÅÛÇø´ Á¤ÇÕ¹ýÀ» ÀÌ¿ëÇÏ¿© ¿Â-¿ÀÇÁ ÇüÅ DNAĨÀÇ Å½»öÀÚ¸¦ ±¸ºÐÇÏ´Â ¹æ¹ýÀ» Á¦¾ÈÇÑ´Ù. ¶ÇÇÑ, ½ºÆÌ ÅÛÇø´ÀÇ ´Ù¾çÇÑ À§Ä¡³ª Å©±â¿¡ µû¸¥ ÀÀ´äÀÇ ÃÖ´ë°ªÀ» ã´Â ÃÖ´ë ÀÀ´ä Ž»ö¹ýÀ» Á¦¾ÈÇÑ´Ù. °¢ ½ºÆÌÀÇ ±³Àâ¹ÝÀÀ ¿©ºÎ¸¸À» ºÐ·ùÇÏ´Â ¿Â-¿ÀÇÁ ÇüÅÂÀÇ DNA ĨÀÇ Å½»öÀÚ¸¦ ±¸ºÐÇÏ´Â ¿ëµµ¿¡ Á¦¾ÈµÈ ¹æ¹ýÀ» Àû¿ëÇÏ¿´´Ù. 2390¸íÀÇ È¯ÀÚ¿¡ ´ëÇÑ ÀÎÀ¯µÎÁ¾ ¹ÙÀÌ·¯½º DNA Ĩ °Ë»ç¿¡ Àû¿ëÇÏ¿©, Ä«¿îÆà Á¤ÇÕµµ¸¦ ±âÁ¸ÀÇ Á¤±Ô»ó°üµµ³ª ¸Þµð¾È°ú ºñ±³ÇÏ¿´´Ù. Ä«¿îÆà Á¤ÇÕµµ°¡ ÃÖ´ë ÀÀ´ä Ž»ö¹ý¿¡ °ü°è¾øÀÌ ÃÖ°íÀÇ ¼º´ÉÀ» º¸¿´´Ù. ½ÇÇè°á°ú À§Ä¡Å½»öÀ» °áÇÕÇÑ Ä«¿îÆà Á¤ÇÕµµ°¡ °¡Àå ÀûÀýÇÏ¿´´Ù.
|
¿µ¹®³»¿ë (English Abstract) |
This paper proposes a nonlinear template matching measure, called counting measure, as a signal detection measure that is defined as the number of on pixels in the spot area. It is applied to classify probes for an on-off type DNA chip, where each probe spot is classified as hybridized or not. The counting measure also incorporates the maximum response search method, where the expected signal is obtained by taking the maximum among the measured responses of the various positions and sizes of the spot template. The counting measure was compared to existing signal detection measures such as the normalized correlation and the median for 2390 patient samples tested on the human papillomavirus (HPV) DNA chip. The counting measure performed the best regardless of whether or not the maximum response search method was used. The experimental results showed that the counting measure combined with the positional search was the most preferable.
|
Å°¿öµå(Keyword) |
ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º
DNA Ĩ
´ë·®°Ë»ç
ÅÛÇø´ Á¤ÇÕ¹ý
ºñ¼±Çü Á¤ÇÕµµ
Ž»öÀÚ ±¸ºÐ
HPV
DNA Chip
High Throughput
Template Matching
Nonlinear Matching Measure
Probe Classification
|
ÆÄÀÏ÷ºÎ |
PDF ´Ù¿î·Îµå
|