JICCE (한국정보통신학회)
Current Result Document :
| 한글제목(Korean Title) |
Activities of Natural Plant Extracts against HIV-1 |
| 영문제목(English Title) |
Activities of Natural Plant Extracts against HIV-1 |
| 저자(Author) |
Jin-Seong Eum
Young-Doo Park
Seong-Karp Hong
|
| 원문수록처(Citation) |
VOL 07 NO. 04 PP. 0576 ~ 0579 (2009. 12) |
한글내용
(Korean Abstract) |
|
영문내용
(English Abstract) |
Anti-HIV-1 activities for the extracts (buthanol, hexane, chloroform, and water) of medicinal plants widely used in the folk medicine were evaluated for screening of anti-AIDS agents. The activities of the extracts to inhibit HIV-1 replication were also analyzed. The 50% effective concentration (EC50) of inhibition activity of the p24 production for chloroform extract of Saphora flavescens, chloroform extract of Herba ephedrae, and hexane extract of Pachyma hoelen Rumph showed 5.8, 29.9, and 37.3 µg/ml, respectively, as good activities. Hexane extract of Sophora flavescens, buthanol extract of Tulipa edulis, hexane extracts of Tulipa edulis, Herba ephedra, and Pachyma hoelen Rumph in the 50% cytotoxic concentration (CC50)in inhibition activities of recombinant HIV-1 RT showed 12.9, 19.5, 11.6, 12.0, and 36.8% at concentration of200 μg/ml, respectively, as good activities. From these results, chloroform extract of Saphora flavescens, chloroform extract of Herba ephedrae, and hexane extract of Pachyma hoelen Rumph were very effective against HIV-1 among all extracts tested. Therefore, we expect these plants will be a useful for anti- HIV-1 therapeutics in future. |
| 키워드(Keyword) |
Anti-HIV-1
extracts
medicinal plants
|
| 파일첨부 |
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