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ÇѱÛÁ¦¸ñ(Korean Title) |
Á¤±Ô»óÈ£Á¤º¸¿Í ÁöÁöº¤Åͱâ°è¸¦ ÀÌ¿ëÇÑ Ãµ½Ä °ü·Ã ´ÜÀÏ¿°±â´ÙÇü¼º À¯ÀüÇü ÀÚ·á ºÐ¼® |
¿µ¹®Á¦¸ñ(English Title) |
Analysis of Asthma Related SNP Genotype Data Using Normalized Mutual Information and Support Vector Machines |
ÀúÀÚ(Author) |
ÀÌÁß¼·
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ÀÓ±Ôö
Jungseob Lee
Seunghyun Kim
Kiseob Shin
Kyucheol Lim
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¿ø¹®¼ö·Ïó(Citation) |
VOL 36 NO. 09 PP. 0691 ~ 0696 (2009. 09) |
Çѱ۳»¿ë (Korean Abstract) |
¼·Ð
õ½Ä¿¡´Â ¾Æ½ºÇǸ° °ú¹ÎÁõ (aspirin hypersensitivity)¿¡ µû¶ó ¾Æ½ºÇǸ° ºÒ³»¼º (aspirin intolerant asthma, AIA)°ú ³»¼º õ½Ä (aspirin tolerant asthma, ATA) µÎ °¡Áö À¯ÇüÀÌ ÀÖ´Ù. õ½Ä°ú °ü·ÃµÈ À¯ÀüÀû À§Çè ¿äÀεéÀº ÁýÁßÀûÀ¸·Î ¶ÇÇÑ ±¤¹üÀ§ÇÏ°Ô ¿¬±¸µÇ°í ÀÖ´Ù. ±×·¯³ª ´ÜÀÏ¿°±â´ÙÇü¼ºµéÀÇ Á¶ÇÕÀÇ È¿°ú¿¡ ´ëÇؼ´Â °ÅÀÇ Æò°¡µÇÁö ¾Ê¾Ò´Ù. º» ³í¹®¿¡¼´Â µÎ À¯ÇüÀÇ Ãµ½Ä Áø´Ü¿¡ À¯¿ëÇÑ ´ÜÀÏ¿°±â´ÙÇü¼ºÀÇ ÃÖ»óÀÇ Á¶ÇÕÀ» ã´Â´Ù.
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º» ³í¹®¿¡¼´Â 246¸íÀÇ Ãµ½ÄȯÀÚµéÀ» Á¶»çÇÏ¿´´Ù. (94¸íÀº ¾Æ½ºÇǸ° ºÒ³»¼º õ½ÄÀ» 152¸íÀº ¾Æ½ºÇǸ° ³»¼º õ½ÄÀ» °¡Áö°í ÀÖ´Ù) ±×¸®°í õ½Ä°ú °ü·ÃµÈ °ÍÀ¸·Î ÃßÃøµÇ´Â 25°³ÀÇ ´ÜÀÏ¿°±â´ÙÇü¼ºµéÀ» ºÐ¼®ÇÏ¿´´Ù. ´ÜÀÏ¿°±â´ÙÇü¼ºÀÇ Á¶ÇÕÀÇ Á¤±Ô»óÈ£Á¤º¸ °ªÀ» °è»êÇÏ¿© ³ôÀº Á¤±Ô»óÈ£Á¤º¸ °ªÀ» °®´Â ´ÜÀÏ¿°±â´ÙÇü¼ºµéÀÇ Á¶ÇÕÀ» ¼±ÅÃÇÏ°í ¼±ÅÃµÈ Á¶ÇÕµéÀÇ ¿¹Ãø Á¤È®µµ¸¦ ÁöÁöº¤Åͱâ°è¸¦ »ç¿ëÇÏ¿© °è»êÇÏ¿´´Ù.
°á°ú
ÃÖ»óÀÇ Á¶ÇÕÀº 4°³Â¥¸®ÀÌ°í ALOX5_p1_1708, B2ADR_q1_46, CCR3_p1_520, CysLTR1_p1_634·Î ±¸¼ºµÈ ¸ðµ¨ÀÌ´Ù. ÀÌ°ÍÀº 0.053ÀÇ Á¤±Ô»óÈ£Á¤º¸ °ª°ú 71.14%ÀÇ ATA Áúº´¿¡ ´ëÇÑ ¿¹Ãø Á¤È®µµ¸¦ °®´Â´Ù. |
¿µ¹®³»¿ë (English Abstract) |
Introduction
There are two types of asthma according to aspirin hypersensitivity: aspirin intolerant asthma (AIA) and aspirin tolerant asthma (ATA). The genetic risk factors that are related with asthma have been investigated intensively and extensively. However the combinatory effects of single nucleotide polymorphisms (SNPs) have hardly been evaluated. In this paper we searched the best set of SNPs that are useful to diagnose the two types of asthma.
Methods
We examined 246 asthmatic patients (94 having aspirin intolerant asthma and 152 having aspirin tolerant asthma) and analyzed 25 SNPs typed in them, which are suspected to be associated with asthma. Normalized mutual information values of combinations of typed SNPs are calculated, and those with high normalized mutual information values are selected. We use support vector machines to evaluate the prediction accuracy of the selected combinations.
Results
The best combination model turns out four-locus and consists of ALOX5_p1_1708, B2ADR_q1_46, CCR3_p1_520, CysLTR1_p1_634. Its normalized mutual information value is 0.053 and the accuracy in predicting ATA disease risk among asthmatic patients is 71.14%. |
Å°¿öµå(Keyword) |
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ÁöÁöº¤Åͱâ°è
asthma
single nucleotide polymorphism
mutual information
support vector machine
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